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Lethal Genes
  • GreyHorseFarmsGreyHorseFarms
    MessagePosts: 186
    I was about to breed to a horse but it says they have lethal genes, what does this mean?
  • Bandit1119Bandit1119
    MessagePosts: 1,263
    A link to the horse is always best so that specific information can be told.

    Without seeing the horse to see what genes they have all I can say that it means there is a chance that a foal may not be born if crossed with another horse with possible lethal genes.

    There are several genes that are outright lethal when in homozygous pairs such as Frame (Olw) and splash 3.

    There are some that are lethal when paired together such as splash 2&3.

    Then you also need to be aware of the white factor for Kit patterns. Certain white genes can increase the white count of a foal and if it maxes out there is a chance at no foal.

    In real life the foal would only survive for a few hours and have had issues with the development of some important body systems (usually the digestive tract is affected I believe)

    Here is Ammits introduction post for Lethal overload which probably explains things more clearly

    http://www.huntandjump.com/forum/discussion/comment/41431#Comment_41431

    I’m not sure if this is the most recent and up to date chart but this shows the interactions between different genes

    https://docs.google.com/spreadsheets/d/1HKUJgwuzbKilAgePgMfMewYd8kU3BKWbe8OcX5QNy_Q/htmlview#
    Post edited by Bandit1119 at 2018-05-23 04:36:31
    Breeding even generation Grullos with KP, Axiom RBG & Wrong Warp, Chinnchilla, Onyx, Phantom Autumn, Bats, Ghosts, Pumpkins, Skulls & Spiders, Plaid, Watercolour genes
  • SandyCreekAcresSandyCreekAcres
    MessagePosts: 10,929
    Splash 2 is also homozygous lethal, as well as when it gets paired with Splash 3.

    It is homzygous frame that causes the incomplete digestive system leading to the death of a foal from impaction colic soon after death.

    Kit is a gene that controls the formation of several vital systems, and it is mutations that break that gene that cause the various white spotting patterns. When a foal inherits two badly broken copies of the Kit gene, its ability to complete those vital functions is destroyed, and the foal dies in the uterus before it can be born. When only a single badly broken copy is inherited, the second one that is not damaged in the same area can pick up the slack, and the foal is born healthy.

    Here is a link to a page on the UC Davis site about their genetic testing services. Although the page deals with testing for three of the Kit mutations, it begins with a mention of the things the Kit gene controls--the development of blood, gonadal, and pigmentary tissues.
    https://www.vgl.ucdavis.edu/services/horse/dominantwhite.php

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